2014 in Biomedicine: Rewriting DNA, Decoding the Brain, and a GMO Paradox

2014 in Biomedicine: Rewriting DNA, Decoding the Brain, and a GMO Paradox

The year began with a landmark event. A decade after the first human genome was decoded at a cost of about $3 billion, the sequencing-machine company Illumina, of San Diego, introduced a new model, the Hyseq X-10, that can do it for around $1,000 per genome.

The system, which costs $10 million and can decode 20,000 genomes a year, was snapped up by large research labs, startup firms like J. Craig Venter’s Human Longevity (which plans to sequence 40,000 people a year), and even by the British government (the U.K. is the first country with a national genome sequencing project).

Francis de Souza, Illumina’s president, predicted that within two years the genomes of about 1.6 million people will have been sequenced.

Cheap sequencing means a deluge of information and a new role for technology designed to handle and exploit “big data.” The search giant Google was the tech company most attuned to the trend, launching a scientific project to collect biological data about healthy humans, and offering to store any genome on its servers for $25 per year. A coalition of genetics researchers backed by Google tried to introduce technical standards, like those that govern the Web, as a way of organizing an “Internet of DNA” over which researchers might share data…

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